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Insulin Resistance - A Root Cause of Excess Weight, Obesity and Other Disorders

Root Cause
The majority of people "with insulin resistance .. are still at significantly increased risk for heart attack, stroke and other diseases."
American Association of Clinical Endocrinologists
Insulin resistance creates increased levels of insulin and glucose in the blood stream, which is a major underlying cause of excess weight and obesity and their links to several other major disorders.

Combating these conditions is crucial for heart disease prevention because rnsulin resistance, excess weight and obesity may increase the risk of developing metabolic syndrome (syndrome x). This latter ailment can damage the cardiovascular system, specifically the lining of the arteries, as well as creating a greater risk of blood clot formation. The kidneys' ability to remove salt is also affected. All of these factors raise the likelihood of developing Cardiovascular Disease (CVD) leading to a heart attack or stroke.

A study published in the Journal of the American Medical Association in December 2002 found that men with metabolic syndrome were associated with a 2.6 - 3.0 times higher CVD mortality rate and a 1.9 - 2.1 higher all-cause mortality rate (1).

This breakthrough in understanding the body's biochemistry remains relatively unknown, even though insulin resistance has reached epidemic proportions. Your doctor may not have explained the crucial link between insulin resistance, excess weight, obesity and metabolic syndrome. You need to understand this link in order to help reverse the symptoms of your condition.

The Insulite System for Excess Weight and Obesity is the first scientifically-designed program that restores your body's ability to overcome metabolic syndrome by reversing insulin resistance.

Pre-diabetes, insulin resistance, excess weight and obesity

As an underlying cause of Pre-diabetes, insulin resistance-linked excess weight and obesity has many factors that contribute to its presence in the body. In essence, our environment and lifestyles have evolved too rapidly for our bodies to keep pace. We are still genetically "wired" to thrive on the entrenched habits of our ancestors, who consumed different, nutrient-rich foods, a diet low in carbohydrates and sustained greater levels of movement and exercise. Some people may also have a genetic predisposition to insulin resistance, while others develop the condition through high stress and unhealthy lifestyles.

Over time, the above factors have damaged the complex ability of the body's cells to properly utilize insulin to convert glucose to energy. This process creates insulin resistance, which can lead to pre-diabetes in two distinct ways.

Firstly, insulin resistance greatly reduces the sensitivity of your cell walls to insulin. So the vital process whereby glucose passes through the cell wall via insulin to be converted into energy is greatly impaired. As a result, excess glucose remains in the blood stream, causing elevated levels of blood sugar, which are sent to the liver. Once there, the sugar is converted into fat and carried via the blood stream throughout the body. This process can lead to weight gain and obesity.

Secondly, insulin resistance-linked excess weight and obesity underlie Pre-Diabetes by raising insulin levels in the blood stream. Unhealthy lifestyles and genetic conditions cause the pancreas to overproduce insulin. The cell, in turn, is overwhelmed by this surplus insulin and protects itself by reducing the number of its insulin receptor sites.

This process leaves too few sites for insulin to carry out its normal function, which is to attach itself to the cell wall and act as a "key in a lock" to allow glucose to pass through the cell wall and be converted into energy. The vastly reduced number of receptor sites in insulin resistant people causes an excess of insulin "rejected" by the cell to float freely in the blood stream, which can damage the cardiovascular system.

Pre-diabetes can be reversed. But if neglected, it can lead to the onset of irreversible Type 2 diabetes, which may require daily insulin injections for the remainder of your life. Type 2 diabetes significantly increases one's risk for blindness, amputation and life-threatening kidney disease, as well as a heart attack and stroke.

Insulin resistance, excess weight, obesity and PCOS (polycystic ovarian syndrome)

PCOS Linked to Insulin ResistancePCOS is a major cause of infertility in women and is closely linked to insulin resistance-related excess weight and obesity. This condition is also known as polycystic ovaries, sclerocystic ovarian disease, stein-leventhal syndrome, chronic anovulatory syndrome and polycystic ovarian disease (PCOD).

It is the most common female endocrine (hormonal) disorder and is characterized, in some cases, by multiple abnormal ovarian cysts. Most ovarian cysts are harmless, fluid-filled sacs containing immature eggs that attach to the ovaries. But multiple cysts, with a typical appearance of a "string of pearls" or "pearl necklace," are a hallmark of PCOS. An estimated 5-10% of women of childbearing age are affected by PCOS, which can prevent ovulation, making pregnancy impossible. Post-menopausal women can also suffer from PCOS.

This reversible condition can be a silent killer. Since the symptoms of PCOS often vary so widely from woman to woman, doctors sometimes misdiagnose the condition. This oversight became a matter of critical concern after a study conducted in 2000 found that women suffering from PCOS have a higher risk of coronary heart disease (2).

Symptoms of PCOS can include excessive weight gain and obesity, irregular, heavy or completely absent periods, ovarian cysts, an overabundance of facial or body hair, Alopecia (male pattern hair loss), acne, skin tags (growths from the skin), Acanthosis Nigricans (brown skin patches) high cholesterol levels, exhaustion or lack of mental alertness, depression, decreased sex drive and excess male hormones.

There is no single pill that reverses insulin resistance, which clearly needs to be controlled and reduced in the case of many people suffering attendant disorders like excess weight gain and obesity, metabolic syndrome, pre-diabetes and PCOS.

What is required is a complete system, including nutraceuticals (vitamins, herbs and minerals that are disease-specific), a realistic exercise program, nutritional guidance and a support network that will help you change unhealthy lifestyle choices.

The Insulite System for Excess Weight and Obesity is scientifically-designed to reverse insulin resistance by restoring the balance of circulating blood sugar and insulin levels - crucial factors in first stabilizing weight and then reducing it to a healthy level. Key components of the Insulite System include advice on a balanced, nutritious diet and regular exercise.

You may be interested in some Frequently Asked Questions (FAQs) about the Insulite System for Weight Gain and Obesity.

(1) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men.
- Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J,
Salonen JT., JAMA. 2002 Dec 4;288(21):2709-16. PMID: 12460094

(2) Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women
- Evelyn O. Talbott; David S. Guzick; Kim Sutton-Tyrrell; Kathleen P. McHugh-Pemu; Jeanne V. Zborowski; Karen E. Remsberg; Lewis H. Kuller, Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20:2414.

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"I have been on the Insulite System for approx 3 months. I have lost 33 lbs, my liver functions are normal and my A1C came back at 5.1, down from 8.03 months ago. I was taking 10 Glucovance pills daily, now I take only 2 pills in the AM. My blood sugar is normal, my energy is higher than it has been in years and I feel great. Insulite along with a change in my diet has changed my life.

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Obesity and Metabolic-Syndrome Articles
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  Boise, Idaho
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Kelly D. Brownell and Derek Yach,
Foreign Policy,
Nov 1, 2005
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  Bakersfield, CA
"There is a clear and consistent scientific literature showing pervasive bias against overweight people. It is logical that the bias begets discrimination. There is now sufficient evidence of discrimination to suggest it may be powerful and occurs across important areas of living.

Studies on employment have shown hiring prejudice in laboratory studies. Subjects report being less inclined to hire an overweight person than a thin person, even with identical qualifications. Individuals make negative inferences about obese persons in the workplace, feeling that such people are lazy, lack self-discipline, and are less competent. One might expect these attributions to affect wages, promotions, and disciplinary actions, and such seems to be the case.

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Rebecca Puhl and Kelly D. Brownell, Bias, Discrimination, and Obesity, Obesity Research 9:788-805 (2001)
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"Middle-age people who are overweight but have normal blood pressure and cholesterol levels are kidding themselves if they think their health is just fine." "Northwestern University researchers tracked 17,643 patients for three decades and found that being overweight in mid-life substantially increased the risk of dying of heart disease later in life – even in people who began the study with healthy blood pressure and cholesterol levels."
Obesity may be an independent risk factor for heart problems, MSNBC
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"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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Article by Dr. Sheri Colberg, Phd, FACSM

"The United States is experiencing an epidemic of obesity. Thirty-four percent of adults are overweight and an additional 30% are obese. Thus, 2 of every 3 Americans have an unhealthy body weight. Obesity contributes to over 300,000 deaths per year, principally through its association with cardiovascular disease, type 2 diabetes, and several cancers. Obesity currently is the second leading cause of preventable death and will soon surpass cigarette smoking, the leading cause. Health economists estimate that obesity costs our nation approximately $100 billion a year. And these figures say nothing about the personal suffering of those affected by obesity."
Testimony of the North American Association for the Study of Obesity (NAASO) before the U.S. House of Representatives Committee on Government Reform, Subcommittee on Human Rights and Wellness, 9.15.2004 (.PDF)

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