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EXCESS WEIGHT, OBESITY AND THE CLINICAL COMPONENTS
OF CARDIOVASCULAR DISEASE


Clinical Components Insulite LaboratoriesExcess weight and obesity can damage the cardiovascular system in a number of ways and lead to an increased risk of a heart attack or stroke:

ATHEROGENIC DYSLIPIDEMIA. A blood fat disorder which consists mainly of high triglycerides and low HDL “good” cholesterol that fosters plaque build-up in artery walls.

ARTERIOSCLEROSIS. Hardening of the walls of the arteries, making them brittle, thick and inflexible, thereby increasing the risk of a stroke.

ATHEROSCLEROSIS. The build-up of
Woman in red eating pasta from a plate in her hand.
Fat tissue "is not like an inert storage depot – it's a very dynamic organ that is actually producing hormones and chemical messengers," said Dr. JoAnn Manson, chief of preventive medicine at Harvard's Brigham and Women's Hospital. These substances can damage blood vessels, increase the risk of blood clots and cause insulin resistance that makes people prone to diabetes – all without elevating blood pressure or cholesterol.
Obesity may be an independent risk factor for heart problems, MSNBC
fatty deposits in the arteries, which interfere with blood flow by narrowing the circumference of the arteries. This condition can begin early in life and then progress as you age, leading to Cardiovascular Disease.

The process begins with damage in the endothelium (inner layer of the artery) followed by plaque build-up. Insulin causes the primary injury to the vessel lining initiating a cascade of chemical factors to the area. These chemical changes affect the integrity and function of the vessel over time and the damage may stimulate the artery wall cells to produce other substances that result in further build-up of plaque.

These cells and surrounding material significantly thicken the endothelium. When the plaque ruptures, a blood clot forms and blocks the artery, stopping the flow of blood. Proven causes of damage to the arterial wall are elevated levels of cholesterol and triglycerides, hypertension (high blood pressure) and tobacco smoke.

HYPERINSULINEMIA. This disorder occurs when insulin progressively loses its effectiveness in sweeping the glucose from the blood stream into the 67 trillion or so cells that constitute our bodies. Insulin levels in the blood rapidly rise to damaging levels and, together with the resulting elevated glucose levels, account for much of the damage to the cardiovascular system.

Clinical Components Insulin ResistanceHYPERTENSION. Also known as high blood pressure, hypertension is a condition commonly associated with narrowing of the arteries. This causes blood to be pumped with excessive force against the artery walls. It is a sign that the heart and blood vessels are being overworked. Untreated, high blood pressure will cause the heart to eventually overwork itself to the point where serious damage can occur. For instance, the heart muscle can thicken (hypertrophy) and function abnormally, or dilate and contract less forcefully (dilated cardiomyopathy). High blood pressure can cause injury to the brain, the eyes (retinopathy) and/or the kidneys (nephropathy). Hypertensive patients are also at increased risk of heart attack and stroke.

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Click here to read about Weight Gain
and Coronary Artery Disease


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"I have been on the Insulite System for approx 3 months. I have lost 33 lbs, my liver functions are normal and my A1C came back at 5.1, down from 8.03 months ago. I was taking 10 Glucovance pills daily, now I take only 2 pills in the AM. My blood sugar is normal, my energy is higher than it has been in years and I feel great. Insulite along with a change in my diet has changed my life.

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  Santa Ana, CA
Obesity and Metabolic-Syndrome Articles
"In less than 3 weeks I've started losing weight again after being "stuck" on Weight Watchers for about a year. I've lost about 4 lbs since starting Insulite but more significantly my blood pressure is well within normal limits now and I can tell my metabolism is better. I am not getting that slump between meals and am able to control between-meal snacking, and I have a lot of energy throughout the day rather than periods where I need to nap. I just ordered the 6 months supply. Thank you!"
Teresa Ruth
  Boise, Idaho
"Obesity is no longer an American disease. Globalization's bounty—economic development, lowered trade costs, and rising incomes—has turned it into a worldwide pandemic for rich and poor alike. If it's left unchecked, the economic health of developing countries will surely be crushed under the weight."
Kelly D. Brownell and Derek Yach,
Foreign Policy,
Nov 1, 2005
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PR
  Bakersfield, CA
"There is a clear and consistent scientific literature showing pervasive bias against overweight people. It is logical that the bias begets discrimination. There is now sufficient evidence of discrimination to suggest it may be powerful and occurs across important areas of living.

Studies on employment have shown hiring prejudice in laboratory studies. Subjects report being less inclined to hire an overweight person than a thin person, even with identical qualifications. Individuals make negative inferences about obese persons in the workplace, feeling that such people are lazy, lack self-discipline, and are less competent. One might expect these attributions to affect wages, promotions, and disciplinary actions, and such seems to be the case.

Overweight women, for the same work, receive less pay than their thin counterparts. This does not seem to be the case for men, but overweight men sort themselves into lower-level jobs. There is evidence that promotion prospects are dimmer for overweight individuals, and there are many examples of people being fired on account of excess weight."
Rebecca Puhl and Kelly D. Brownell, Bias, Discrimination, and Obesity, Obesity Research 9:788-805 (2001)
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MS
  Stuarts Draft, VA
"Middle-age people who are overweight but have normal blood pressure and cholesterol levels are kidding themselves if they think their health is just fine." "Northwestern University researchers tracked 17,643 patients for three decades and found that being overweight in mid-life substantially increased the risk of dying of heart disease later in life – even in people who began the study with healthy blood pressure and cholesterol levels."
Obesity may be an independent risk factor for heart problems, MSNBC
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Sarah
  Longmont, CO
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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Article by Dr. Sheri Colberg, Phd, FACSM


"The United States is experiencing an epidemic of obesity. Thirty-four percent of adults are overweight and an additional 30% are obese. Thus, 2 of every 3 Americans have an unhealthy body weight. Obesity contributes to over 300,000 deaths per year, principally through its association with cardiovascular disease, type 2 diabetes, and several cancers. Obesity currently is the second leading cause of preventable death and will soon surpass cigarette smoking, the leading cause. Health economists estimate that obesity costs our nation approximately $100 billion a year. And these figures say nothing about the personal suffering of those affected by obesity."
Testimony of the North American Association for the Study of Obesity (NAASO) before the U.S. House of Representatives Committee on Government Reform, Subcommittee on Human Rights and Wellness, 9.15.2004 (.PDF)

"I started your product and found it really boosts my system, helping me get off ground zero, and stop the spiral downwards. It gave me the energy to start exercising and prepare healthy meals.

You are all very supportive, even though I am on the other side of the world (Australia). I am very glad that I am on your product, your weekly messages are also very encouraging, when I am finding things a bit harder. Thank you for everything."
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  Perth, Australia
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