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EXCESS WEIGHT, OBESITY AND BREAST CANCER


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"A study of more than 44,000 women found that the more weight a woman gained, the greater her risk for all types, stages, and grades of breast cancer....women who gained more than 60 pounds were almost twice as likely to have ductal type breast tumors and more than 1.5 times more likely to have lobular type cancers."
Heather Spencer Feigelson, American Cancer Society, Being overweight raises breast cancer risk, MSNBC
More than 192,000 women in the U.S. alone learn each year that they have breast cancer. The figure for women around the world runs into millions.

Approximately 5-10% of these women have a hereditary form of the disease. Changes, called alterations or mutations, in certain genes make some women more susceptible to developing breast and other types of cancer. Inherited alterations in the genes called BRCA1 (Breast Cancer Gene 1) and BRCA2 (Breast Cancer Gene 2) are involved in many cases of hereditary breast cancer, as well as ovarian cancer. Researchers are searching for other genes that may also increase a woman's cancer risk.

The likelihood that breast and/or ovarian cancer is associated with BRCA1 or 2 is highest in families with a history of multiple cases of breast cancer, as well as in cases of both breast and ovarian cancer, in examples of one or more family members with two primary cancers (original tumors at different sites) or an Ashkenazi (Eastern European) Jewish background.

However, not every woman in such families carries an alteration in BRCA1 or 2 and not every cancer in such families is linked to alterations in these genes.

A new survey suggests the risk from BRCA1 and 2 breast cancer mutations in young women may be reduced by reversing Insulin Resistance, which can be an underlying factor in excess weight, and obesity.

Breast Cancer and Excess Weight LossAn international team of scientists found that women aged between 18 and 30 who carry BRCA1 and 2 can significantly reduce their risk of developing breast cancer by losing weight. Research showed that women who lost at least 10 lbs between those ages reduced their risk of cancer by up to 65%. But the survey also produced evidence that gaining 10 lbs in the same age group increased the women's risk of developing cancer before the age of 40. (1)

Being overweight after Menopause was already known to increase the risk to women. But authors of the new study say it is the first to link the weight of women of reproductive age with breast cancer.

Researchers from the U.S., Canada and Poland looked at more than 2,000 women carrying faulty or mutated BRCA1 or 2 breast cancer genes. BRCA1 and 2 are tumor-suppressor genes that, when functioning normally, help repair damage to DNA in a process that also prevents tumor development.

In 1994, researchers discovered that women who carry BRCA1 or 2 mutations are at higher risk of developing both breast and ovarian cancer than women who do not have these genetic mutations.

Breast Cancer and Excess Weight lossThe women in the latest study were tested for BRCA1 and 2 genes and questioned about their weight at ages 18, 30 and 40. It was found that women carrying the BRCA1 gene who lost weight saw the greatest benefit.

At 18, they had an average weight of 142.5 lbs. By the age of 30, these women had lost a minimum of 10 lbs and an average of 18.6 lbs and experienced a reduction in risk of up to 65%. Weight loss also reduced the risk of cancer for women with the defective breast cancer gene BRCA2, but not to a significant degree.

On the other hand, gaining weight substantially heightened the risk of breast cancer for BRCA1 mutation carriers who had borne at least two children. These women increased their risk of being diagnosed with breast cancer before the age of 40 by 44% if they gained 10 lbs between the ages of 18 and 30.

The study suggests that carrying extra fat around the center of the body could affect ovarian hormones and glucose metabolism, increasing the likelihood of the onset of Insulin Resistance. A reduction in insulin receptor sites on cell membranes is present in people with Insulin Resistance. The lack of sites means that insulin cannot perform its normal role of allowing sufficient blood glucose to pass through cells to be used as energy. As a result, glucose and insulin levels become unhealthy.

Excess glucose in the bloodstream from Insulin Resistance is converted and stored as fat which can result in obesity. Excess insulin can also increase the risk of Pre-Diabetes, which if left unchecked may lead to Type 2 Diabetes that can only be managed.

High insulin levels can also affect a woman's hormones and be a factor in Polycystic Ovarian Syndrome (PCOS), a leading cause of female infertility, as well as skin conditions, excess body hair, and male pattern baldness. PCOS sufferers are also at greater risk for Cardiovascular Disease.

Insulin Resistance can, however, be reversed. But, if left unchecked, Insulin Resistance can also lead to the cluster of cardiovascular risk factors called Metabolic Syndrome or Syndrome X.

Insulite Research Breast CancerLead researcher Dr. Steven Narod of the University of Toronto, Canada, wrote: "The results from this study suggest that weight loss in early adult life protects against early-onset BRCA-associated breast cancers. Weight gain should also be avoided, particularly among BRCA1 mutation carriers, who elect to have at least two pregnancies."

"Weight gain should also be avoided, particularly among BRCA1 mutation carriers, who elect to have at least two pregnancies." There is no single pill that will reverse excess weight and obesity. But there are ways to address Insulin Resistance, which is often the underlying cause of all these conditions.

There is no single pill that will reverse excess weight and obesity. But there are ways to address Insulin Resistance which is often an underlying cause.

If you wish optimum health, you should consider a system that combines potent nutraceuticals (vitamins, minerals, amino acids, enzymes, and botanicals formulated to address specific conditions), a realistic exercise program, nutritional guidance, and a support system that will help you change unhealthy lifestyle choices.

Click here to read about the Insulite System for Excess Weight and Obesity which can help you reverse insulin resistance and manage excessive weight. The system's formulations include InsulX, which features vanadium — a compound that can help decrease body fat, and suppress appetite.

You may be interested in some Frequently Asked Questions (FAQs) about the Insulite System for Excess Weight and Obesity.

(1) Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
- Kotsopoulos J, Olopado OI, Ghadirian P, Lubinski J, Lynch HT, Isaacs C, Weber B, Kim-Sing C, Ainsworth P, Foulkes WD, Eisen A, Sun P, Narod SA., Breast Cancer Res. 2005;7(5):R833-43. Epub 2005 Aug 19. PMID: 16168130


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"I have been on the Insulite System for approx 3 months. I have lost 33 lbs, my liver functions are normal and my A1C came back at 5.1, down from 8.03 months ago. I was taking 10 Glucovance pills daily, now I take only 2 pills in the AM. My blood sugar is normal, my energy is higher than it has been in years and I feel great. Insulite along with a change in my diet has changed my life.

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Marta Garcia
  Santa Ana, CA
Obesity and Metabolic-Syndrome Articles
"In less than 3 weeks I've started losing weight again after being "stuck" on Weight Watchers for about a year. I've lost about 4 lbs since starting Insulite but more significantly my blood pressure is well within normal limits now and I can tell my metabolism is better. I am not getting that slump between meals and am able to control between-meal snacking, and I have a lot of energy throughout the day rather than periods where I need to nap. I just ordered the 6 months supply. Thank you!"
Teresa Ruth
  Boise, Idaho
"Obesity is no longer an American disease. Globalization's bounty—economic development, lowered trade costs, and rising incomes—has turned it into a worldwide pandemic for rich and poor alike. If it's left unchecked, the economic health of developing countries will surely be crushed under the weight."
Kelly D. Brownell and Derek Yach,
Foreign Policy,
Nov 1, 2005
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
PR
  Bakersfield, CA
"There is a clear and consistent scientific literature showing pervasive bias against overweight people. It is logical that the bias begets discrimination. There is now sufficient evidence of discrimination to suggest it may be powerful and occurs across important areas of living.

Studies on employment have shown hiring prejudice in laboratory studies. Subjects report being less inclined to hire an overweight person than a thin person, even with identical qualifications. Individuals make negative inferences about obese persons in the workplace, feeling that such people are lazy, lack self-discipline, and are less competent. One might expect these attributions to affect wages, promotions, and disciplinary actions, and such seems to be the case.

Overweight women, for the same work, receive less pay than their thin counterparts. This does not seem to be the case for men, but overweight men sort themselves into lower-level jobs. There is evidence that promotion prospects are dimmer for overweight individuals, and there are many examples of people being fired on account of excess weight."
Rebecca Puhl and Kelly D. Brownell, Bias, Discrimination, and Obesity, Obesity Research 9:788-805 (2001)
"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

I am so excited about the positive changes in my health and I can't wait to see where I am six months from now, yet alone the year. Thank you again!"
MS
  Stuarts Draft, VA
"Middle-age people who are overweight but have normal blood pressure and cholesterol levels are kidding themselves if they think their health is just fine." "Northwestern University researchers tracked 17,643 patients for three decades and found that being overweight in mid-life substantially increased the risk of dying of heart disease later in life – even in people who began the study with healthy blood pressure and cholesterol levels."
Obesity may be an independent risk factor for heart problems, MSNBC
"Thank you so much for putting me on the right road!"
Sarah
  Longmont, CO
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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Article by Dr. Sheri Colberg, Phd, FACSM


"The United States is experiencing an epidemic of obesity. Thirty-four percent of adults are overweight and an additional 30% are obese. Thus, 2 of every 3 Americans have an unhealthy body weight. Obesity contributes to over 300,000 deaths per year, principally through its association with cardiovascular disease, type 2 diabetes, and several cancers. Obesity currently is the second leading cause of preventable death and will soon surpass cigarette smoking, the leading cause. Health economists estimate that obesity costs our nation approximately $100 billion a year. And these figures say nothing about the personal suffering of those affected by obesity."
Testimony of the North American Association for the Study of Obesity (NAASO) before the U.S. House of Representatives Committee on Government Reform, Subcommittee on Human Rights and Wellness, 9.15.2004 (.PDF)

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